Iridium-catalyzed asymmetric double allylic alkylation of azlactone: efficient access to chiral α-amino acid derivatives
Xiang Cheng, Chong Shen, Xiu‐Qin Dong, Chun‐Jiang Wang
Abstract
An unprecedented Ir-catalyzed enantioselective double allylic alkylation of less bulky cyclic imine glycinate (azlactone) was rationally designed and developed, providing facile access to a series of bisallylated chiral amino acid derivatives.
Topics & Concepts
IridiumTsuji–Trost reactionEnantioselective synthesisAlkylationImineCatalysisChemistryKinetic resolutionAllylic rearrangementCombinatorial chemistryAmino acidStereochemistryOrganic chemistryBiochemistryAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry Methods