Computational investigation on lipid bilayer disruption induced by amphiphilic Janus nanoparticles: combined effect of Janus balance and charged lipid concentration
Thanh Danh Nguyen, James X. Wu, Patrick M. Corrigan, Ying Li
Abstract
the combination of hydrophobic and electrostatic interactions. This finding is validated by testing the current Janus NP design on a bacterial membrane-mimicking model. This computational study may serve as a foundation for further studies aimed at optimizing the properties of Janus NPs for specific antimicrobial applications.
Topics & Concepts
JanusAmphiphileLipid bilayerBilayerJanus particlesNanoparticleBiophysicsChemistryBalance (ability)NanotechnologyMaterials scienceMembraneBiochemistryOrganic chemistryCopolymerBiologyPolymerNeuroscienceLipid Membrane Structure and BehaviorPickering emulsions and particle stabilizationSurfactants and Colloidal Systems