A ZBP1 isoform blocks ZBP1-mediated cell death
Zhiyu Cai, Puqi Wu, Hao Liang, Yu-Ze Xie, Bo-Xin Zhang, Cailing He, Congrong Yang, Hongda Li, Wei Mo, Zhang‐Hua Yang
Abstract
cells die spontaneously when ZBP1-S is deleted, indicating that cell death driven by ZBP1 is under the control of ZBP1-S. Thus, our findings reveal that alternative splicing of Zbp1 represents autogenic inhibition for regulating ZBP1 signaling and indicate that uncoupling of Z-NA with ZBP1 could be an effective strategy against autoinflammations.
Topics & Concepts
Gene isoformProgrammed cell deathCell biologyBiologyApoptosisGeneticsGeneUbiquitin and proteasome pathwaysAutophagy in Disease and Therapyinterferon and immune responses