KLF5-Modulated lncRNA NEAT1 Contributes to Tumorigenesis by Acting as a Scaffold for BRG1 to Silence GADD45A in Gastric Cancer
Pei Ma, Yutian Pan, Fan Yang, Yuan Fang, Wei-Tao Liu, Chenhui Zhao, Tao Yu, Mengyan Xie, Xingming Jing, Xi Wu, Chongqi Sun, Wei Li, Tongpeng Xu, Yongqian Shu
Abstract
. Taken together, our data support the importance of NEAT1 in promoting GC tumorigenesis and indicate that NEAT1 might be a diagnostic and therapeutic target in GC.
Topics & Concepts
Gene knockdownCarcinogenesisGene silencingCell growthCancer researchCell cycle checkpointBiologyLong non-coding RNADownregulation and upregulationCell cycleCancerApoptosisCell biologyChemistryMolecular biologyGeneGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCancer-related gene regulation