Methodological advances enabled by the construction of a synthetic yeast genome
Daniel Schindler, Roy Walker, Yizhi Cai
Abstract
The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae , as well as a 17 th de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.
Topics & Concepts
EukaryoteSynthetic biologySaccharomyces cerevisiaeConstruct (python library)GenomeComputational biologyYeastGenomicsBiologyBiotechnologyGeneticsGeneComputer scienceProgramming languageRNA and protein synthesis mechanismsGenomics and Chromatin DynamicsRNA modifications and cancer