The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells
Rajesh Abraham Jacob, Cassandra R. Edgar, Jérémie Prévost, Steven M. Trothen, Antony Lurie, Mitchell J. Mumby, Alexa Galbraith, Frank Kirchhoff, S. M. Mansour Haeryfar, Andrés Finzi, Jimmy D. Dikeakos
Abstract
T cells.
Topics & Concepts
Downregulation and upregulationCell biologyBiologyReceptorImmune checkpointCytotoxic T cellImmune systemImmunologyImmunotherapyBiochemistryGeneIn vitroGalectins and Cancer BiologyImmune Cell Function and InteractionCancer Mechanisms and Therapy