Structural biology of SMC complexes across the tree of life
Frank Bürmann, Jan Löwe
Abstract
Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can be explained by an inherent motor activity that extrudes large DNA loops while the complexes move along their substrate. Here, we review recent structural insights into the architecture and conservation of these molecular machines, their interaction with DNA, and the conformational changes that are linked to their ATP hydrolysis cycle.
Topics & Concepts
BiologyDNAStructural biologyATP hydrolysisComputational biologyTree (set theory)BiophysicsEvolutionary biologyGeneticsBiochemistryATPaseEnzymeMathematical analysisMathematicsDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanismsRNA modifications and cancer