Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model
Kun-Hung Lee, Wan-Ching Yen, Wen‐Hsing Lin, Peichen Wang, You-Liang Lai, Yu‐Chieh Su, Chunyu Chang, Cai-Syuan Wu, Yuchen Huang, Chen-Ming Yang, Ling-Hui Chou, Teng‐Kuang Yeh, Chiung‐Tong Chen, Chuan Shih, Hsing‐Pang Hsieh
Abstract
mesylate delayed the MC38 murine colon tumor growth and reversed the immunosuppressive tumor microenvironment with the increased M1/M2 ratio.
Topics & Concepts
ChemistryOrally activePharmacologyStructure–activity relationshipBiological activityOral administrationIn vitroBiochemistryMedicineImmune cells in cancerCancer, Stress, Anesthesia, and Immune ResponseChemokine receptors and signaling