ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Guanqun Liu, Jung‐Hyun Lee, Zachary M. Parker, Dhiraj Acharya, Jessica J. Chiang, Michiel van Gent, William Riedl, Meredith E. Davis-Gardner, Effi Wies, Cindy Chiang, Michaela U. Gack
Topics & Concepts
ISG15MDA5Innate immune systemBiologyRIG-IInterferonVirologyCoronavirusIntrinsic immunityIRF3ImmunityCell biologyImmune systemImmunologyGeneRNA interferenceGeneticsRNAUbiquitinMedicineCoronavirus disease 2019 (COVID-19)PathologyInfectious disease (medical specialty)Diseaseinterferon and immune responsesInflammasome and immune disordersCytokine Signaling Pathways and Interactions