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Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells

Mohammad Mahboob Alam, Azizah M. Malebari, Syed Nazreen, Thikryat Neamatallah, Abdulraheem S. A. Almalki, Ahmed A. Elhenawy, Rami J. Obaid, Meshari A. Alsharif

2021Bioorganic & Medicinal Chemistry67 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryThymidylate synthaseIC50Docking (animal)MCF-7ApoptosisCancer cellBiochemistryStereochemistryIn vitroCancerBiologyHuman breastGeneticsNursingFluorouracilMedicineSynthesis and biological activityClick Chemistry and ApplicationsCancer therapeutics and mechanisms
Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells | Litcius