An endoplasmic reticulum-targeting iridium(<scp>iii</scp>) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment
Yi Rong, Zhongxian Fan, Zhijie Yu, Wei Li, Han Shen, Huaiyi Huang, Xiaojuan Hao, Zizhuo Zhao, Jinquan Wang
Abstract
IrC induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling the tumor microenvironment in mice.
Topics & Concepts
Tumor microenvironmentImmunotherapyImmunogenic cell deathEndoplasmic reticulumCancer researchMelanomaChemistryCancer immunotherapyProgrammed cell deathApoptosisImmune systemCell biologyTumor cellsBiologyImmunologyBiochemistryCancer Immunotherapy and BiomarkersNanoplatforms for cancer theranosticsPhagocytosis and Immune Regulation