Cobalt-Catalyzed Csp<sup>3</sup>–Csp<sup>3</sup> Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides
Ferdinand H. Lutter, Lucie Grokenberger, Maximilian Benz, Paul Knochel
Abstract
A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is reported using a combination of 20% CoCl2 and chelating nitrogen ligands. The method allows the construction of molecules with alkyl chains bearing sensitive functional groups at room temperature.
Topics & Concepts
ChemistryAlkylReagentNegishi couplingCobaltCatalysisAcetonitrileChelationCombinatorial chemistryMoleculePrimary (astronomy)Polymer chemistryOrganic chemistryAstronomyPhysicsCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis