Synthesis and Evaluation of a Library of Alternating Amphipathic Copolymers to Solubilize and Study Membrane Proteins
Adrian H. Kopf, Odette Lijding, Barend O. W. Elenbaas, Martijn C. Koorengevel, Justyna M. Dobruchowska, Cornelis A. van Walree, J. Antoinette Killian
Abstract
. Relevant polymer properties were found to include hydrophobic balance, size and positioning of substituents, rigidity, and electronic effects. The library thus contributes to the rational design of copolymers for the study of MPs.
Topics & Concepts
CopolymerAmphiphileMembraneChemistryMaleic acidTurbidimetryPolymer chemistryPolymerSMA*Combinatorial chemistryOrganic chemistryChromatographyBiochemistryMathematicsCombinatoricsLipid Membrane Structure and BehaviorSupramolecular Self-Assembly in MaterialsSupramolecular Chemistry and Complexes