Combined KOH/BEt<sub>3</sub> Catalyst for Selective Deaminative Hydroboration of Aromatic Carboxamides for Construction of Luminophores
Wubing Yao, Jiali Wang, Aiguo Zhong, Jinshan Li, Jianguo Yang
Abstract
The selective catalytic C–N bond cleavage of amides into value-added amine products is a desirable but challenging transformation. Molecules containing iminodibenzyl motifs are prevalent in pharmaceutical molecules and functional materials. Here we established a combined KOH/BEt3 catalyst for deaminative hydroboration of acyl-iminodibenzyl derivatives, including nonheterocyclic carboxamides, to the corresponding amines. This novel transition-metal-free methodology was also applied to the construction of Clomipramine and luminophores.
Topics & Concepts
ChemistryHydroborationCatalysisAmine gas treatingMoleculeAminationCombinatorial chemistryOrganic chemistryOrganoboron and organosilicon chemistryChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis