Litcius/Paper detail

Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency

Philip M. Zakas, Sharon C. Cunningham, Ann Doherty, Eva B. van Dijk, Raed Ibraheim, Stephanie Yu, Befikadu D Mekonnen, Brendan Lang, Elizabeth J. English, Gang Sun, Miles C. Duncan, Matthew S Benczkowski, Robert C. Altshuler, Malvenderjit Jagjit Singh, Emily S. Kibbler, Gülen Yesilbag Tonga, Zijun Wang, Z. Jane Wang, Guangde Li, An Ding, James B. Rottman, Yashvi Bhavsar, Cormac Purcell, Rachit Jain, Ryan Alberry, Nathaniel Roquet, Yanfang Fu, Robert J. Citorik, Jacob R. Rubens, Michael C. Holmes, Cecilia Cotta‐Ramusino, William Querbes, Ian E. Alexander, William E. Salomon

2024Molecular Therapy21 citationsDOIOpen Access PDF

Topics & Concepts

TransgeneVector (molecular biology)TransposaseGenetic enhancementBiologyViral vectorGene deliveryAdeno-associated virusTransgenesisGene expressionGeneTransposable elementVirologyComputational biologyMolecular biologyRecombinant DNAGeneticsGenomeReproductive biologyEmbryogenesisVirus-based gene therapy researchRNA Interference and Gene DeliveryCRISPR and Genetic Engineering