Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study
Tuğba GÜRBÜZ, Şebnem Alanya Tosun, Ayşegül Çebi, Oya Gökmen, Murat Usta
Abstract
Polycystic ovary syndrome (PCOS) may have an increased risk for the development of systemic and metabolic pathogenesis such as cardiovascular diseases, insulin resistance (IR), diabetes mellitus (DM) and dyslipidemia. However, there is no reliable marker to show the relation. Fetuin-A is an adipokine whereas paraoxonase-1 (PON-1) is a high-density lipoprotein-linked enzyme to demonstrate oxidative stress. This study aimed to evaluate serum fetuin-A and PON-1 levels in infertile PCOS women based on body mass index (BMI).
Topics & Concepts
MedicinePolycystic ovaryBody mass indexInternal medicineInsulin resistanceDyslipidemiaAdipokineProspective cohort studyEndocrinologyMetabolic syndromeParaoxonaseGastroenterologyObesityOxidative stressOvarian function and disordersParaoxonase enzyme and polymorphismsApelin-related biomedical research