Burkholderia pseudomallei Clinical Isolates Are Highly Susceptible <i>In Vitro</i> to Cefiderocol, a Siderophore Cephalosporin
Delaney Burnard, Gemma Robertson, Andrew Henderson, Caitlin Falconer, Michelle J. Bauer, Kyra Cottrell, Ian Gassiep, Robert Norton, David L. Paterson, Patrick N. A. Harris
Abstract
Cefiderocol is a cephalosporin designed to treat multidrug-resistant Gram-negative infections. By forming a chelated complex with ferric iron, cefiderocol is transported into the periplasmic space via bacterial iron transport systems and primarily binds to penicillin-binding protein 3 (PBP3) to inhibit peptidoglycan synthesis. This mode of action results in cefiderocol having greater in vitro activity against many Gram-negative bacilli than currently used carbapenems, β-lactam/β-lactamase inhibitor combinations, and cephalosporins.
Topics & Concepts
SiderophoreCephalosporinMicrobiologyBiologyPeriplasmic spaceMode of actionBurkholderia pseudomalleiBurkholderiaBacteriaAntibioticsBiochemistryEscherichia coliGeneGeneticsBurkholderia infections and melioidosisAntibiotic Resistance in BacteriaChemical Looping and Thermochemical Processes