Immune profiling of COVID-19 patients

Priscilla N. Kelly

2020Science97 citationsDOI

Abstract

Coronavirus Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. [eabc8511][1], p. [1210][2] [1]: /lookup/doi/10.1126/science.abc8511 [2]: /lookup/doi/10.1126/science.abc6261

Topics & Concepts

Coronavirus disease 2019 (COVID-19)Profiling (computer programming)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune systemVirologyBetacoronavirusCoronavirus InfectionsComputational biologyBiologyImmunologyMedicineComputer scienceOutbreakInfectious disease (medical specialty)PathologyDiseaseOperating systemSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesImmune responses and vaccinations