PMDTA-catalyzed multicomponent synthesis and biological activity of 2-amino-4<i>H</i>-chromenes containing a phosphonate or phosphine oxide moiety
Ádám Tajti, Kármen Emőke Szabó, Nóra Popovics-Tóth, Javad Iskanderov, Franc Perdih, László Hackler, Beáta Kari, László G. Puskás, Erika Bálint
Abstract
values determined, several derivatives showed moderate or promising activity against mouse fibroblast (NIH/3T3) and human promyelocytic leukemia (HL-60) cells. Furthermore, three (2-amino-3-cyano-4H-chromen-4-yl)phosphine oxides were active against selected Gram-positive bacteria.
Topics & Concepts
PhosphonateMoietyChemistryPhosphine oxidePhosphineCatalysisOxideCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryMulticomponent Synthesis of HeterocyclesSulfur-Based Synthesis TechniquesSynthesis of Organic Compounds