N‐Heterocyclic carbene‐catalyzed Atroposelective Annulation for Access to Pyrrolo[3,4‐<i>b</i>]pyridines Derivatives with C−N Axial Chirality
Yanting Li, Xiaoyong Duan, Yamei Wei, Jiahan Li, Xiaojie Ren, Jing Qi
Abstract
Abstract An N‐heterocyclic carbene (NHC) catalyzed atroposelective [3+3] annulation of enals with α‐ aminomaleimides is developed. In this strategy, a series of atropisomeric pyrrolo[3,4‐ b ]pyridine bearing various substituents and substitution patterns are generated in good yields with excellent enantioselectivities.
Topics & Concepts
AnnulationChemistryCarbeneCatalysisAxial chiralityPyridineChirality (physics)Medicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryEnantioselective synthesisQuarkPhysicsChiral symmetry breakingQuantum mechanicsNambu–Jona-Lasinio modelAxial and Atropisomeric Chirality SynthesisSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods