SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease
Qing-Qing Dong, Yu-Chi Tu, Pan Gao, Qian-Qian Liao, Peng Zhou, Hui Zhang, Hua-Pan Shu, Lulu Sun, Feng Li, Lijun Yao
Abstract
Thus, it is justifiable to conclude that SGK3 promotes VC in CKD by enhancing the expression and activities of Pit-1, which indicate that SGK3 could be a therapeutic target for VC in CKD.
Topics & Concepts
Downregulation and upregulationHyperphosphatemiaVascular smooth muscleEndocrinologyInternal medicineSGK1Ubiquitin ligaseKidney diseaseChemistryMedicineUbiquitinBiochemistryGlucocorticoidSmooth muscleGeneParathyroid Disorders and TreatmentsMagnesium in Health and DiseaseIon Transport and Channel Regulation