An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
Jin Zhou, Jeremy M. Simon, Chengheng Liao, Cheng Zhang, Lianxin Hu, Giada Zurlo, Xijuan Liu, Cheng Fan, Austin J. Hepperla, Liwei Jia, Vanina Toffessi Tcheuyap, Hua Zhong, Roy Elias, Jin Ye, W. Mike Henne, Payal Kapur, Deepak Nijhawan, James Brugarolas, Qing Zhang
Topics & Concepts
BiologyCarcinogenesisH3K4me3Clear cell renal cell carcinomaGene silencingDownregulation and upregulationEffectorCell growthCell biologyCancer researchEpigeneticsCellGene expressionBiochemistryGeneRenal cell carcinomaPromoterInternal medicineMedicineLipid metabolism and biosynthesisUbiquitin and proteasome pathwaysCancer, Hypoxia, and Metabolism