Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents
Farhana Islam, Tasdique M. Quadery, Ruoli Bai, Lerin R. Luckett‐Chastain, Ernest Hamel, Michael A. Ihnat, Aleem Gangjee
Topics & Concepts
ChemistryTubulinPaclitaxelIn vivoMicrotubule polymerizationPyrimidineMicrotubuleStereochemistryIn vitroCell culturePharmacologyBiochemistryCancerBiologyCell biologyBiotechnologyGeneticsSynthesis and biological activityCancer therapeutics and mechanismsSynthesis and Biological Evaluation