The influence of surface charge on the tumor-targeting behavior of Fe<sub>3</sub>O<sub>4</sub> nanoparticles for MRI
Saisai Yue, Xin Zhang, Yuping Xu, Lichong Zhu, Junwei Cheng, Yuanyuan Qiao, Suyang Dai, Jialin Zhu, Ni Jiang, Hao Wu, Peisen Zhang, Yi Hou
Abstract
studies, the protein corona exhibited completely different effects on the active and passive cancer-targeting capability of the particles. The particles presented active cancer-targeting ability if there was enough interaction time between the particles and cells. This was mainly due to the dynamic evolution of the protein corona, the proteins of which may be outcompeted by the cancer cell membrane and determine the targeting abilities. Unfortunately, the protein corona also inevitably accelerated RES/MPS uptake after the particles were injected into the body, which almost completely disabled the active targeting abilities of the particles. We believe that this in-depth understanding of protein corona will provide new ideas on the tumor-targeting mechanisms of nanoparticles and present a feasible approach to designing targeted drugs in the future.