A self-assembling CXCR4-targeted pyroptosis nanotoxin for melanoma therapy
Zheng Zhao, Yingbin Huang, Jing Wang, Hongsheng Lin, Fei Cao, Shuxin Li, Yin Li, Ziqian Li, Xuekui Liu
Abstract
The self-assembling nanotoxin T22-PE24 that specifically targets CXCR4 was designed to selectively deliver the cytotoxic toxin PE24 to treat CXCR4 + melanoma via activating caspase 3/GSDME pathways in which initially “cold” tumors will become “hot”.
Topics & Concepts
PyroptosisMelanomaTumor microenvironmentCancer researchImmunotherapyProgrammed cell deathChemistryMedicineApoptosisTumor cellsImmune systemImmunologyBiochemistryInflammasome and immune disordersImmunotherapy and Immune Responsesinterferon and immune responses