<i>P. aeruginosa</i> tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in cystic fibrosis
Zhongyou Li, Roxanna Barnaby, Amanda Nymon, Carolyn Roche, Katja Koeppen, Alix Ashare, Deborah A. Hogan, Scott A. Gerber, Douglas J. Taatjes, Thomas H. Hampton, Bruce A. Stanton
2024American Journal of Physiology-Lung Cellular and Molecular Physiology13 citationsDOIOpen Access PDF
Abstract
The experiments in this report identify a novel mechanism, whereby tobramycin reduces inflammation in two models of CF. Tobramycin increased the secretion of tRNA-fMet halves in OMVs secreted by P. aeruginosa, which reduced the OMV-LPS-induced inflammatory response in primary cultures of CF-HBEC and in mouse lung, an effect predicted to reduce lung damage in pwCF.
Topics & Concepts
Cystic fibrosisInflammationVesicleLungTransfer RNAMicrobiologyFibrosisChemistryPathologyMedicineBiologyMembraneImmunologyInternal medicineBiochemistryRNAGeneCystic Fibrosis Research AdvancesBacterial Infections and VaccinesBacterial biofilms and quorum sensing