Cross Dehydrogenative Coupling of SF<sub>4</sub>-Alkyne with Tetrahydroisoquinolines
Arvind K. Yadav, Putri Nur Arina Mohd Ariff, Koki Kawai, Seishu Ochiai, Srikanth Reddy Narra, Norio Shibata
Abstract
This study introduces a dual-catalytic method for cross-dehydrogenative coupling (CDC) between tetrahydroisoquinolines and Py-SF 4 -alkyne using visible-light photoredox catalysis. This protocol enables selective C(sp 3 )–H alkynylation, expanding the synthetic toolkit for SF 4 -based molecules. Demonstrating efficiency and substrate versatility, this approach opens new avenues in hexacoordinated tetrafluorinated sulfur chemistry and CDC strategies and holds significant promise for drug discovery and materials science.
Topics & Concepts
AlkyneChemistryCatalysisCombinatorial chemistryDrug discoveryMoleculeOrganic chemistryBiochemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions