In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Friedrichsen, Sune Boris Nygård, Kim Kristensen
Topics & Concepts
DextromethorphanCYP1A2PharmacologyCYP2B6PharmacokineticsCYP3A4OmeprazoleCytochrome P450CYP2D6ChemistryCYP3ADrug interactionMidazolamDownregulation and upregulationCYP2C9CaffeineMedicineEndocrinologyEnzymeBiochemistrySedationGenePharmacogenetics and Drug MetabolismDiabetes Treatment and ManagementReceptor Mechanisms and Signaling