Arylation of aryllithiums with <i>S</i>-arylphenothiazinium ions for biaryl synthesis
Tatsuya Morofuji, Tatsuki Yoshida, Ryosuke Tsutsumi, Masahiro Yamanaka, Naokazu Kano
Abstract
Aryllithiums are one of the most common and important aryl nucleophiles; nevertheless, methods for arylation of aryllithums to produce biaryls have been limited. Herein, we report arylation of aryllithiums with S-arylphenothiazinium ions through selective ligand coupling of intermediary sulfuranes. Various unsymmetrical biaryls could be obtained without transition-metal catalysis.
Topics & Concepts
IonCombinatorial chemistryChemistryOrganic chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloids