Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators
Gehad Lotfy, Yasmine M. Abdel Aziz, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Marwa M. Abu‐Serie, Mohamed Teleb, Alexander Dömlingꝉ, Assem Barakat
Topics & Concepts
ChemistryMdm2ApoptosisMTT assayCancer researchBiochemistryCell biologyBiologyCancer-related Molecular PathwaysUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors