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Synthesis and efficacy of norfloxacin loaded onto magnetic hydrogel nanocomposites

Nehal Salahuddin, Ahmed Rehab, Sahar Emad

2021RSC Advances14 citationsDOIOpen Access PDF

Abstract

well diffusion method, and showed significant activity compared to the unloaded drug. Furthermore, an antitumor efficacy against HCT-116, HepG-2, PC3 and MCF-7 cancer cells revealed the highest cytotoxic efficacy with no influence on healthy cells. These nanodrugs, retaining both antibacterial and anticancer efficacy, have a talented therapeutic potential because of their selective cytotoxicity, connected with the ability to minimize the risk of bacterial infection in a cancer patient who is frequently immunocompromised.

Topics & Concepts

NanocompositeMethacrylateBiocompatible materialDrug deliveryMagnetic nanoparticlesNorfloxacinNanoparticleMaterials scienceChemical engineeringPolymer chemistryNanotechnologyChemistryCopolymerPolymerComposite materialBiomedical engineeringCiprofloxacinMedicineAntibioticsBiochemistryEngineeringNanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems
Synthesis and efficacy of norfloxacin loaded onto magnetic hydrogel nanocomposites | Litcius