Design of chiral ferrocenylphosphine-spiro phosphonamidite ligands for ruthenium-catalyzed highly enantioselective coupling of 1,2-diols with amines
Xiao Yi, Yirui Chen, An Huang, Dingguo Song, Jiaying He, Fei Ling, Weihui Zhong
Abstract
A series of chiral ferrocene-backbone phosphines-spiro phosphonamidite ligands was developed for ruthenium-catalyzed enantioselective access to a broad range of β-amino alcohols from 1,2-diols and amines via the borrowing-hydrogen prciniple.
Topics & Concepts
Enantioselective synthesisChemistryRutheniumFerroceneCatalysisCombinatorial chemistryOrganic chemistryElectrochemistryElectrodePhysical chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis