Copper‐Catalyzed C(<i>sp</i><sup><i>3</i></sup>)‐Amination of Ketone‐Derived Dihydroquinazolinones by Aromatization‐Driven C−C Bond Scission
Xin‐Yang Lv, Roman Abrams, Rubén Martı́n
Abstract
Abstract Herein, we describe the development of a copper‐catalyzed C( sp 3 )‐amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open‐shell species arising from homolytic C−C bond‐cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.
Topics & Concepts
Bond cleavageAromatizationChemistryAminationHomolysisCatalysisKetoneCopperOrganic chemistryMedicinal chemistryRadicalCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsQuinazolinone synthesis and applications