Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2-deficient mice
Philippe Haouzi, Marissa McCann, Nicole Tubbs
Abstract
When life-threatening doses of fentanyl are used in mice, the β-arrestin 2 pathway appears to play a critical role in the recovery from opioid overdose. This observation calls into question the use of G protein-biased μ-opioid receptor agonists, as a strategy for safer opioid analgesic drugs.
Topics & Concepts
FentanylVentilation (architecture)AnesthesiaControl of respirationMedicineRespiratory rateRespiratory systemRespiratory minute volumeSedationApneaPharmacologyHeart rateInternal medicineEngineeringMechanical engineeringBlood pressureReceptor Mechanisms and SignalingNeuroscience of respiration and sleepNeurotransmitter Receptor Influence on Behavior