Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Doğan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone
Abstract
behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.
Topics & Concepts
ChemistryPositron emission tomographyRadiosynthesisRadiochemistryIn vivoEndogenyCarbon fibersNuclear medicineBiochemistryMedicineBiotechnologyComposite numberComposite materialMaterials scienceBiologyRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsCancer, Hypoxia, and Metabolism