Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer’s disease
Javan Lee Tze Han, Karen Ka Lam Pang, Sheila Rui Xia Ang, Mahima Sharma, Sreedharan Sajikumar
Abstract
10.1186/s40035-021-00247-0
Topics & Concepts
Synaptic plasticityNeuroscienceHippocampal formationChemistryBiologyBiochemistryReceptorEpigenetics and DNA MethylationGenetics and Neurodevelopmental DisordersAlzheimer's disease research and treatments