Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager
Zhuo Yang, Yingqin Hou, Geramie Grande, Jong Hyun Cho, Chao Wang, Yujie Shi, Jaroslav Žák, Yue Wan, Ke Qin, Dongfang Liu, John R. Teijaro, Richard A. Lerner, Peng Wu
Topics & Concepts
CytolysisSialidaseCellCytotoxic T cellAntigenSialic acidCancer researchT cellN-Acetylneuraminic acidImmunosurveillanceChimeric antigen receptorBiologyGlycanOncolytic virusCytotoxicityImmunologyChemistryMolecular biologyIn vitroBiochemistryImmune systemNeuraminidaseTumor cellsVirusGlycoproteinMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchImmunotherapy and Immune Responses