Intermolecular trifluoromethyl-alkenylation of alkenes enabled by metal-free photoredox catalysis
Arun Dattatray Kulthe, Prathama S. Mainkar, Srirama Murthy Akondi
Abstract
A three-component and redox-neutral trifluoromethylative alkenylation of unactivated alkenes with β-nitrostyrenes has been developed under visible-light. This metal-free protocol utilizes the easy to handle Langlois reagent (CF3SO2Na) as the CF3 source and is suitable for various unactivated alkenes and β-nitrostyrenes, affording a series of trifluoromethylated aromatic alkenes under mild conditions in good to excellent yields.
Topics & Concepts
TrifluoromethylIntermolecular forcePhotoredox catalysisChemistryCatalysisMetalAlkenePhotochemistryOrganic chemistryCombinatorial chemistryPhotocatalysisMoleculeAlkylFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques