Estimating the prognosis of esophageal squamous cell carcinoma based on The Cancer Genome Atlas (TCGA) of m6A methylation-associated genes
Yu Pu, Xianfeng Lu, Xueqin Yang, Yi Yang, Dong Wang, Mengxia Li, Wei Guan, Mingfang Xu
Abstract
Background: N6-methyladenosine (m6A) mRNA modification is the most prevalent in certain tumors. However, its expression profile and prognostic value in human esophageal squamous cell carcinoma (ESCC) remains unknown. Methods: ) expression. Results: (HR: 0.948; 95% CI: 0.895-1.003; P=0.0.064) overexpression predicted better overall survival (OS) of ESCC patients. Furthermore, based on prognostic factors, the high-risk (H-R) cohort was found to have worse survival than the low-risk (L-R) cohort (P<0.001). Conclusions: in the H-R group.
Topics & Concepts
MedicineHazard ratioOncologyProportional hazards modelInternal medicineConfidence intervalReceiver operating characteristicCohortEsophageal cancerEsophageal squamous cell carcinomaSurvival analysisNomogramCarcinomaCancer researchCancerRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation