Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress
Mayson H. Alkhatib, Shaza A. Alyamani, Faiza Abdu
Abstract
evaluation of the MTX-NE COCO treatment revealed that the antioxidant enzymes activities of the brain and lung tissues, catalase, superoxide dismutase, and glutathione reductase, were relatively raised while the malondialdehyde amount was diminished when compared to the free MTX treatment. In conclusion, combining MTX with coconut oil in a NE had improved its efficacy while ameliorating its oxidative stress effect on the brain and lungs.
Topics & Concepts
CocoCoconut oilOxidative stressPharmacologyMalondialdehydeSuperoxide dismutaseIC50AntioxidantCatalaseMethotrexateChemistryNeurotoxicityGlutathione reductaseToxicityBiochemistryMedicineGlutathione peroxidaseIn vitroInternal medicineOrganic chemistryArtificial intelligenceComputer scienceCoconut Research and ApplicationsPeanut Plant Research StudiesNanocomposite Films for Food Packaging