Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
Cuige Zhu, Anna Rogers, Karama Asleh, Jennifer Won, Dongxia Gao, Samuel Leung, Shan Li, Kiran Vij, Jian Zhu, Jason M. Held, Zhongsheng You, Torsten O. Nielsen, Jieya Shao
Abstract
phosphorylation is a DDR-specific enhancer of VCP function and a potential predictive biomarker for chemotherapy treatments.
Topics & Concepts
DNA damageChromatinDNA repairProteostasisBiologyCancer researchBreast cancerPhosphorylationChromatin remodelingCancerCell biologyDNABiochemistryGeneticsEndoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathwaysDNA Repair Mechanisms