CHEK2 deficiency increase the response to PD-1 inhibitors by affecting the tumor immune microenvironment
Pingping Xu, Yaqi Gao, Shanshan Jiang, Yun Cui, Yuanhong Xie, Zi‐Ran Kang, Yingxuan Chen, Danfeng Sun, Jing‐Yuan Fang
Topics & Concepts
CHEK2Cancer researchImmune systemTumor microenvironmentCytotoxic T cellImmune checkpointImmunotherapyBiologyCD8DNA damageImmunologyMutationGeneGeneticsGermline mutationDNAIn vitroCancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsCancer-related Molecular Pathways