Asymmetric addition of Grignard reagents to ketones: culmination of the ligand-mediated methodology allows modular construction of chiral tertiary alcohols
Claudio Monasterolo, Ryan O'Gara, Saranna E. Kavanagh, Sadbh E. Byrne, Bartosz Bieszczad, Órla Meadhbh Murray, Michael Wiesinger, Rebecca A. Lynch, Kirill Nikitin, Declan G. Gilheany
Abstract
)-L12. The work described herein marks the finalization of our ongoing effort towards the establishment of an effective and broadly applicable methodology for the asymmetric Grignard synthesis of chiral tertiary alcohols.
Topics & Concepts
CulminationModular designReagentLigand (biochemistry)ChemistryCombinatorial chemistryTertiary alcoholsGrignard reagentOrganic chemistryStereochemistryComputer scienceCatalysisPhysicsProgramming languageReceptorAstronomyBiochemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisCoordination Chemistry and Organometallics