A novel model of chronic limb ischemia to therapeutically evaluate the angiogenic effects of drug candidates
Kenichiro Shimatani, Hiromu Sato, Atsuhiro Saito, Masao Sasai, Kenichi Watanabe, Kazuhiko Mizukami, Masazumi Kamohara, Shigeru Miyagawa, Yoshiki Sawa
Abstract
We developed a chronic and severe hindlimb ischemia (HLI) mouse model for preclinical research on critical limb ischemia (CLI). This model partially reflects human CLI pathology in that it does not show spontaneous restoration of blood flow or expression of angiogenic genes in the ischemic limb. This novel model may be valuable for therapeutic evaluation of the angiogenic effects of CLI drug candidates.
Topics & Concepts
DrugMedicineLimb ischemiaIschemiaPharmacologyInternal medicineAngiogenesis and VEGF in CancerPeripheral Artery Disease ManagementCoronary Interventions and Diagnostics