Immune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant models
S. Elizabeth Franks, Kellsye P. Fabian, Ginette S. Santiago-Sánchez, Benjamin Wolfson, James W. Hodge
Abstract
model TC-1.
Topics & Concepts
TIGITCancer researchMedicineImmune checkpointImmune systemImmunotherapyTumor microenvironmentCD8Cytotoxic T cellImmunologyBiologyIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmunotherapy and Immune Responses