Quality Metric to Assess Adequacy of Hydrogel Rectal Spacer Placement for Prostate Radiation Therapy and Association of Metric Score With Rectal Toxicity Outcomes
Craig E. Grossman, Michael R. Folkert, Stephanie Lobaugh, Neil Desai, Marisa Kollmeier, Daniel Gorovets, Sean M. McBride, Robert Timmerman, Zhigang Zhang, Michael J. Zeléfsky
Abstract
Purpose: Although hydrogel spacer placement (HSP) minimizes rectal dose during prostate cancer radiotherapy, its potential benefit for modulating rectal toxicity could depend upon the achieved prostate-rectal separation. We therefore developed a quality metric associated with rectal dose reduction and late rectal toxicity among patients treated with prostate stereotactic body radiotherapy (SBRT).Materials and Methods: A quality metric consisting of prostate-rectal interspace (PRI) measurements from axial T2-weighted MRI simulation images was applied to 42 men enrolled on a multi-institutional phase II study using HSP with prostate SBRT (45 Gy in 5 fractions). A score of 0, 1, or 2 was assigned to a PRI measurement of <0.3 cm, 0.3-0.9 cm, or ≥1 cm, respectively. An overall spacer quality score (SQS) was computed from individual scores at rectal midline and ±1 cm laterally, located at the prostate base, mid-gland, and apex. Associations of SQS with rectal dosimetry and late toxicity were evaluated.Results: The majority of the analyzed cohort had an SQS of 1 (n=17; 41%) or 2 (n=18; 43%). SQS was associated with maximum rectal point dose (rectal Dmax; p=0.002), maximum dose to 1 cc of rectum (D1cc; p=0.004), and volume of rectum receiving ≥100% of prescription dose (V45; p=0.046) and ≥40 Gy (V40; p=0.005). SQS was also associated with a higher incidence of (p=0.01) and highest-graded late rectal toxicity (p=0.01). Among the 20 men who developed late grade ≥1 rectal toxicity, 57%, 71%, and 22% had an SQS of 0, 1, and 2, respectively. Men with an SQS of 0 or 1 compared to 2 had 4.67-fold (95% CI: 0.72-30.11) or 8.40-fold (95% CI: 1.83-38.57), respectively, greater odds of developing late rectal toxicity.Conclusion: We developed a reliable and informative metric for assessing HSP, which appears to be associated with rectal dosimetry and late rectal toxicity after prostate SBRT.