Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by <i>POLG</i> Mutation
Kristina Xiao Liang, Anbin Chen, Atefeh Kianian, Cecilie Katrin Kristiansen, Tsering Yangzom, Jessica Furriol, Lena Elise Høyland, Mathias Ziegler, Torbjørn Kråkenes, Charalampos Tzoulis, Evandro Fei Fang, Gareth J. Sullivan, Laurence A. Bindoff
Abstract
mutations leads not only to intrinsic defects in energy metabolism affecting both neurons and astrocytes, but also to neurotoxic damage driven by astrocytes. These findings reveal a novel role for dysfunctional astrocytes that contribute to the pathogenesis of POLG diseases.
Topics & Concepts
MutationMitochondrial DNANeurotoxicityMitochondrionBiologyGeneticsNeuroscienceMedicineInternal medicineToxicityGeneMitochondrial Function and PathologyNeuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments