Literature Overview of the IL-17 Inhibition from Psoriasis to COVID-19
Yulin Zou, Zudong Meng
Abstract
The COVID-19 pandemic has posed a serious problem for drug anti-viral efficacy in combatting the cytokine storm triggered by SARS-CoV-2. From dermato-epidemiological studies conducted on psoriatic and other rheumatological patients, IL-17 inhibitors seem to attenuate or even prevent the cytokine storm and thus ICU referral. Furthermore, both in-vivo and in-vitro experiments suggest that IL-17 plays a key role in SARS-CoV-2 infection progression. Due to this evidence, we decided to summarize the literature findings on IL-17 inhibitors and COVID-19, maintaining psoriasis as the referral disease to better understand the extent of drug effects on the immune system.
Topics & Concepts
Cytokine stormPsoriasisMedicineCoronavirus disease 2019 (COVID-19)PandemicImmunologyImmune systemCytokineDiseaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ReferralEpidemiologyIntensive care medicineInfectious disease (medical specialty)Internal medicineFamily medicinePsoriasis: Treatment and PathogenesisCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19