Deoxofluorination of (Hetero)aromatic Acids
Serhii Trofymchuk, Maksym Ya. Bugera, Anton A. Klipkov, Bohdan Razhyk, S. Semenov, Karen V. Tarasenko, Viktoriia S. Starova, Olga A. Zaporozhets, Oksana Tananaiko, Anatoliy N. Alekseenko, Yurii Pustovit, Oleksandr M. Kiriakov, Igor I. Gerus, Andrei A. Tolmachev, Pavel K. Mykhailiuk
Abstract
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.
Topics & Concepts
ChemistryOrganic chemistryTrifluoromethylSulfurCinnamic acidAlkylFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation