Calmodulin Binding Activates <i>Chromobacterium</i> CopC Effector to ADP-Riboxanate Host Apoptotic Caspases
Yaxin Liu, Huan Zeng, Yanjie Hou, Zilin Li, Lin Li, Xiaocui Song, Jingjin Ding, Feng Shao, Yue Xu
Abstract
Programmed cell death is a suicidal defense mechanism for eukaryotes to combat pathogen infection. In the evolutionary arms race with the host, bacteria are endowed with ingenious tactics to block host cell death to facilitate their replication. Here, we report that the C. violaceum effector CopC ADP-riboxanates caspase-7/8/9, enabled by interacting with the host factor calmodulin, to block host cell apoptosis, illustrating a unique and sophisticated strategy adopted by the pathogen to counteract host defense.
Topics & Concepts
EffectorCaspaseCell biologyVirulenceBiologyType three secretion systemChemistryProgrammed cell deathBiochemistryApoptosisGeneToxin Mechanisms and ImmunotoxinsCell death mechanisms and regulationMicrobial Metabolism and Applications